Small RNAome profiling from human skeletal muscle: novel miRNAs and their targets associated with cancer cachexia.

ABSTRACT:

Background

MicroRNAs (miRs) are small non-coding RNAs that regulate gene (mRNA) expression. Although the pathological role of miRs have been studied in muscle wasting conditions such as myotonic and muscular dystrophy, their roles in cancer cachexia (CC) are still emerging.

Objectives

The objectives are (i) to profile human skeletal muscle expressed miRs; (ii) to identify differentially expressed (DE) miRs between cachectic and non-cachectic cancer patients; (iii) to identify mRNA targets for the DE miRs to gain mechanistic insights; and (iv) to investigate if miRs show potential prognostic and predictive value.

Methods

Study subjects were classified based on the international consensus diagnostic criteria for CC. Forty-two cancer patients were included, of which 22 w

SUBMITTER: Narasimhan A 

PROVIDER: S-EPMC5476855 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature