Host-Microbial Interactions in Idiopathic Pulmonary Fibrosis.

ABSTRACT:

Rationale

Changes in the respiratory microbiome are associated with disease progression in idiopathic pulmonary fibrosis (IPF). The role of the host response to the respiratory microbiome remains unknown.

Objectives

To explore the host-microbial interactions in IPF.

Methods

Sixty patients diagnosed with IPF were prospectively enrolled together with 20 matched control subjects. Subjects underwent bronchoalveolar lavage (BAL), and peripheral whole blood was collected into PAXgene tubes for all subjects at baseline. For subjects with IPF, additional samples were taken at 1, 3, and 6 months and (if alive) 1 year. Gene expression profiles were generated using Affymetrix Human Gene 1.1 ST arrays.

Measurements and main results

By network analysis of gene expression da

SUBMITTER: Molyneaux PL 

PROVIDER: S-EPMC5476909 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature