Sphingosine-1-phosphate metabolism: A structural perspective.

ABSTRACT: Sphingolipids represent an important class of bioactive signaling lipids which have key roles in numerous cellular processes. Over the last few decades, the levels of bioactive sphingolipids and/or their metabolizing enzymes have been realized to be important factors involved in disease development and progression, most notably in cancer. Targeting sphingolipid-metabolizing enzymes in disease states has been the focus of many studies and has resulted in a number of pharmacological inhibitors, with some making it into the clinic as therapeutics. In order to better understand the regulation of sphingolipid-metabolizing enzymes as well as to develop much more potent and specific inhibitors, the field of sphingolipids has recently taken a turn toward structural biology. The last decade has see

SUBMITTER: Pulkoski-Gross MJ 

PROVIDER: S-EPMC5476942 | biostudies-literature | 2015 Jul-Aug

REPOSITORIES: biostudies-literature