Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma.

ABSTRACT:

Purpose

To evaluate local control after 21-Gy radiation therapy (RT) to the primary site in patients with high-risk neuroblastoma.

Methods and materials

After receiving dose-intensive chemotherapy and gross total resection (GTR), 246 patients (aged 1.2-17.9 years, median 4.0 years) with high-risk neuroblastoma underwent RT to the primary site at Memorial Sloan Kettering from 2000 to 2014. Radiation therapy consisted of 21 Gy in twice-daily fractions of 1.5 Gy each. Local failure (LF) was correlated with biologic prognostic factors and clinical findings at the time of diagnosis and start of RT.

Results

Median follow-up of surviving patients was 6.4 years. Cumulative incidence of LF was 7.1% at 2 years after RT and 9.8% at 5 years after RT. The isolated LF rate was 3.0%

SUBMITTER: Casey DL 

PROVIDER: S-EPMC5476959 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature