Palladium-catalyzed ligand-promoted site-selective cyanomethylation of unactivated C(sp³)-H bonds with acetonitrile.

ABSTRACT: The direct cyanomethylation of unactivated sp³ C-H bonds of aliphatic amides was achieved via palladium catalysis assisted by a bidentate directing group with good functional group compatibility. This process represents the first example of the direct cross-coupling of sp³ C-H bonds with acetonitrile. Considering the importance of the cyano group in medicinal and synthetic organic chemistry, this reaction will find broad application in chemical research.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5477045 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature