A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption.

ABSTRACT:

Background

Atherosclerotic plaque rupture is the culprit event which underpins most acute vascular syndromes such as acute myocardial infarction. Novel biomarkers of plaque rupture could improve biological understanding and clinical management of patients presenting with possible acute vascular syndromes but such biomarker(s) remain elusive. Investigation of biomarkers in the context of de novo plaque rupture in humans is confounded by the inability to attribute the plaque rupture as the source of biomarker release, as plaque ruptures are typically associated with prompt down-stream events of myocardial necrosis and systemic inflammation.

Methods

We developed a novel approach to identify potential biomarkers of plaque rupture by integrating plaque imaging, using optical cohe

SUBMITTER: Lee R 

PROVIDER: S-EPMC5477097 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature