Transcriptomic profiles of aging in naive and memory CD4⁺ cells from mice.

ABSTRACT:

Background

CD4+ T cells can be broadly divided into naïve and memory subsets, each of which are differentially impaired by the aging process. It is unclear if and how these differences are reflected at the transcriptomic level. We performed microarray profiling on RNA derived from naïve (CD44^low) and memory (CD44^high) CD4+ T cells derived from young (2-3 month) and old (28 month) mice, in order to better understand the mechanisms of age-related functional alterations in both subsets. We also performed follow-up bioinformatic analyses in order to determine the functional consequences of gene expression changes in both of these subsets, and identify regulatory factors potentially responsible for these changes.

Results

We found 185 and 328 genes differenti

SUBMITTER: Taylor J 

PROVIDER: S-EPMC5477126 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature