Immunogenicity of Augmented Compared With Standard Dose Hepatitis B Vaccine in Pediatric Patients on Dialysis: a Midwest Pediatric Nephrology Consortium Study.

ABSTRACT:

Background and objectives

Patients on maintenance dialysis have a higher risk of unresponsiveness to hepatitis B vaccination and loss of hepatitis B immunity. Adult guidelines recommend augmented dosing (40 mcg/dose), resulting in improved response in adults. We sought to determine whether children on dialysis mount a similar antibody response when given standard or augmented dosing of hepatitis B vaccine.

Design, setting, participants, & measurements

This is a retrospective review of patients on dialysis aged <19 years from May 1, 2008 to May 1, 2013 at 12 pediatric dialysis units. Hepatitis B surface antibody (HBsAb) titers ≥10 mIU/ml were defined as protective.

Results

A total of 187 out of 417 patients received one or more hepatitis B vaccine boosters. The median

SUBMITTER: Misurac JM 

PROVIDER: S-EPMC5477206 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature