Clinical and Histopathologic Characteristics Associated with Renal Outcomes in Lupus Nephritis.

ABSTRACT:

Background and objectives

The prognostic significance of histopathologic (sub)classes in the current classification of lupus nephritis (LN) is controversial. We analyzed clinical and histopathologic predictors of renal outcome in LN outside the framework of the classification.

Design, setting, participants, & measurements

Variables (50 histopathologic and ten clinical) were tested in mixed, linear, and Cox regression models for their association with renal flare, ESRD, and eGFR during follow-up (1, 5, and 10 years) in 105 patients with LN who underwent biopsy from 1987 to 2011. The Cockcroft-Gault (normalized to a body surface area of 1.73 m²) and Schwartz formulas were used to calculate eGFR for adults and children, respectively.

Results

During median foll

SUBMITTER: Rijnink EC 

PROVIDER: S-EPMC5477219 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature