Adiponectin protects against incident hypertension independent of body fat distribution: observations from the Dallas Heart Study.

ABSTRACT: Excess adipose tissue has been implicated in the pathogenesis of insulin resistance and atherosclerosis and is a key risk factor for blood pressure (BP) elevation. However, circulating levels of adiponectin, a protein produced by adipose tissue and widely implicated in the pathogenesis of insulin resistance and atherosclerosis, are inversely proportional to adiposity. The relationship between adiponectin and incident hypertension has not been determined in the general US population. Normotensive participants (n = 1233) enrolled in the Dallas Heart Study, a multiethnic, probability-based population sample of Dallas County adults were followed for median of 7 years. Retroperitoneal, intraperitoneal, visceral, and subcutaneous adipose tissue were measured at baseline by magnetic resonance ima

SUBMITTER: Peri-Okonny PA 

PROVIDER: S-EPMC5477232 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature