Polymorphism in asparagine synthetase is associated with overall survival of hepatocellular carcinoma patients.

ABSTRACT:

Background

Recently, it is reported that asparagine synthetase (ASNS) is an independent predictor of surgical survival in hepatocellular carcinoma (HCC) patients. It is also reported that activating transcription factor 6 (ATF6) expression is decreased in HCC patients. So in the present study, we explored the relationship between ASNS and ATF6, and whether ASNS expression was associated with HCC.

Methods

ATF6 was over expressed in 3 HCC cell lines (HepG2, HepG2.2.15 and SMMC-7721). We then examined the mRNA levels of ASNS and ATF6 in 90 HCC patients, 77 chronic hepatitis B patients and 70 controls. We also genotyped 2 functional polymorphisms in ASNS in a case-control study.

Results

The expression of ASNS was significantly elevated when ATF6 was over expressed. The ex

SUBMITTER: Li W 

PROVIDER: S-EPMC5477286 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature