MiR-629-3p may serve as a novel biomarker and potential therapeutic target for lung metastases of triple-negative breast cancer.

ABSTRACT:

Background

Different breast cancer subtypes show distinct tropisms for sites of metastasis. Notably, the lung is the most common site for the first distant recurrence in triple-negative breast cancer (TNBC). The identification of novel biomarkers for lung metastasis is of great importance to improving the outcome of TNBC. In this study, we sought to identify a microRNA (miRNA)-based biomarker and therapeutic target for lung metastasis of TNBC.

Methods

A total of 669 patients without de novo stage IV TNBC were recruited for this study. miRNA profiling was conducted in the discovery cohort. Diagnostic accuracy and prognostic values of candidate miRNAs were evaluated in the training and validation cohorts, respectively. The biological functions of candidate miRNAs, as well as p

SUBMITTER: Wang J 

PROVIDER: S-EPMC5477310 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature