Forced expiration measurements in mouse models of obstructive and restrictive lung diseases.

ABSTRACT:

Background

Pulmonary function measurements are important when studying respiratory disease models. Both resistance and compliance have been used to assess lung function in mice. Yet, it is not always clear how these parameters relate to forced expiration (FE)-related parameters, most commonly used in humans. We aimed to characterize FE measurements in four well-established mouse models of lung diseases.

Method

Detailed respiratory mechanics and FE measurements were assessed concurrently in Balb/c mice, using the forced oscillation and negative pressure-driven forced expiration techniques, respectively. Measurements were performed at baseline and following increasing methacholine challenges in control Balb/c mice as well as in four disease models: bleomycin-induced fibrosis,

SUBMITTER: Devos FC 

PROVIDER: S-EPMC5477381 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature