Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα.

ABSTRACT: Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin α_Mβ₂, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. However, the role of Mac-1 in thrombosis is undefined. Here we report that mice with Mac-1 deficiency (Mac-1^-/-) or mutation of the Mac-1-binding site for GPIbα have delayed thrombosis after carotid artery and cremaster microvascular injury without affecting parameters of haemostasis. Adoptive wild-type leukocyte transfer rescues the thrombosis defect in Mac-1^-/- mice, and Mac-1-dependent regulation of the transcription factor Foxp1 contributes to thrombosis as

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5477519 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature