Single-cell transcriptome of early embryos and cultured embryonic stem cells of cynomolgus monkeys.

ABSTRACT: In mammals, the development of pluripotency and specification of primordial germ cells (PGCs) have been studied predominantly using mice as a model organism. However, divergences among mammalian species for such processes have begun to be recognized. Between humans and mice, pre-implantation development appears relatively similar, but the manner and morphology of post-implantation development are significantly different. Nevertheless, the embryogenesis just after implantation in primates, including the specification of PGCs, has been unexplored due to the difficulties in analyzing the embryos at relevant developmental stages. Here, we present a comprehensive single-cell transcriptome dataset of pre- and early post-implantation embryo cells, PGCs and embryonic stem cells (ESCs) of cynomolgu

SUBMITTER: Nakamura T 

PROVIDER: S-EPMC5477564 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature