Erythropoietin protects against rhabdomyolysis-induced acute kidney injury by modulating macrophage polarization.

ABSTRACT: Erythropoietin (EPO) is a well-known hormone that is clinically used for the treatment of anemia. Very recently, an increasing body of evidence showed that EPO could still regulate bioactivities of macrophages. However, the details about the immunomodulatory effect of EPO on macrophages are not fully delineated, particularly in the setting of renal damages. Therefore, in the present study, we determined whether EPO could exert an impact on the dynamics of macrophages in a well-established model of rhabdomyolysis-induced acute kidney injury and explored the potential mechanisms. EPO was found to ameliorate kidney injuries by reducing macrophages recruitment and promoting phenotype switch toward M2 macrophages in vivo. It was also confirmed that EPO could directly suppress pro-inflammatory r

SUBMITTER: Wang S 

PROVIDER: S-EPMC5477572 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature