Genetic Variation and Neuroplasticity: Role in Rehabilitation After Stroke.

ABSTRACT:

Background and purpose

In many neurologic diagnoses, significant interindividual variability exists in the outcomes of rehabilitation. One factor that may impact response to rehabilitation interventions is genetic variation. Genetic variation refers to the presence of differences in the DNA sequence among individuals in a population. Genetic polymorphisms are variations that occur relatively commonly and, while not disease-causing, can impact the function of biological systems. The purpose of this article is to describe genetic polymorphisms that may impact neuroplasticity, motor learning, and recovery after stroke.

Summary of key points

Genetic polymorphisms for brain-derived neurotrophic factor (BDNF), dopamine, and apolipoprotein E have been shown to impact neuroplasticit

SUBMITTER: Stewart JC 

PROVIDER: S-EPMC5477674 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature