Transcriptome profiling of Staphylococci-infected cow mammary gland parenchyma.

ABSTRACT:

Background

Genome-wide gene expression profiling allows for identification of genes involved in the defense response of the host against pathogens. As presented here, transcriptomic analysis and bioinformatics tools were applied in order to identify genes expressed in the mammary gland parenchyma of cows naturally infected with coagulase-positive and coagulase-negative Staphylococci.

Results

In cows infected with coagulase-positive Staphylococci, being in 1st or 2nd lactation, 1700 differentially expressed genes (DEGs) were identified. However, examination of the 3rd or 4th lactations revealed 2200 DEGs. Gene ontology functional classification showed the molecular functions of the DEGs overrepresented the activity of cytokines, chemokines, and their receptors. In cows infect

SUBMITTER: Kosciuczuk EM 

PROVIDER: S-EPMC5477815 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature