Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer.

ABSTRACT:

Background

Heterogeneity of muscle-invasive bladder cancer (MIBC) has been characterized using whole-genome mRNA expression data, showing distinct molecular and clinicopathological characteristics by subtypes. However, associations between risk factors and molecular subtypes have not been reported.

Methods

Four previously published schemes were used to categorize molecular subtypes in 372 MIBC patients from the Cancer Genome Atlas (TCGA). Data on gene expression (RNA-seq), demographic, and clinicopathological characteristics were retrieved through TCGA data portal. Polytomous logistic regression was used to estimate the associations of subtypes by different schemes with age at diagnosis, obesity, and smoking.

Results

While some quantitative variation was evident, dist

SUBMITTER: Sun X 

PROVIDER: S-EPMC5477976 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature