High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance.

ABSTRACT: Antibiotic-resistant infections kill approximately 23,000 people and cost $20,000,000,000 each year in the United States alone despite the widespread use of small-molecule antimicrobial combination therapy. Antibiotic combinations typically have an additive effect: the efficacy of the combination matches the sum of the efficacies of each antibiotic when used alone. Small molecules can also act synergistically when the efficacy of the combination is greater than the additive efficacy. However, synergistic combinations are rare and have been historically difficult to identify. High-throughput identification of synergistic pairs is limited by the scale of potential combinations: a modest collection of 1,000 small molecules involves 1 million pairwise combinations. Here, we describe a high-thr

SUBMITTER: Wambaugh MA 

PROVIDER: S-EPMC5478098 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature