Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles.

ABSTRACT: Pretargeted positron emission tomography (PET) imaging based on bioorthogonal chemical reactions has proven its potential in immunoimaging. It may also have great potential in nanotheranostic applications. Here, we report the first successful pretargeted PET imaging of trans-cyclooctene-modified mesoporous silicon nanoparticles, using ¹⁸F-labeled tetrazine as a tracer. The inverse electron-demand Diels-Alder cycloaddition (IEDDA) reaction was fast, resulting in high radioactivity accumulation in the expected organs within 10 min after the administration of the tracer. The highest target-to-background ratio was achieved 120 min after the tracer injection. A clear correlation between the efficiency of the in vivo IEDDA labeling reaction and the injected amount of the tracer

SUBMITTER: Keinanen O 

PROVIDER: S-EPMC5478181 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature