The Transcriptional Landscape of p53 Signalling Pathway.

ABSTRACT: Although recent cancer genomics studies have identified a large number of genes that were mutated in human cancers, p53 remains as the most frequently mutated gene. To further elucidate the p53-signalling network, we performed transcriptome analysis on 24 tissues in p53^+/+ or p53^-/- mice after whole-body X-ray irradiation. Here we found transactivation of a total of 3551 genes in one or more of the 24 tissues only in p53^+/+ mice, while 2576 genes were downregulated. p53 mRNA expression level in each tissue was significantly associated with the number of genes upregulated by irradiation. Annotation using TCGA (The Cancer Genome Atlas) database revealed that p53 negatively regulated mRNA expression of several cancer therapeutic targets or pathways such as BTK

SUBMITTER: Tanikawa C 

PROVIDER: S-EPMC5478243 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature