Adverse Events Associated with Antipsychotic Use in Hospitalized Older Adults After Cardiac Surgery.

ABSTRACT:

Objectives

To evaluate in-hospital adverse events associated with typical and atypical antipsychotic medications (APMs) after cardiac surgery.

Design

Retrospective cohort study.

Setting

Nationwide inpatient database, 2003 to 14.

Participants

Individuals (mean age 70) newly treated with oral atypical (n = 2,580) or typical (n = 1,126 APMs) after coronary artery bypass grafting or valve surgery (N = 3,706).

Measurements

In-hospital mortality, arrhythmia, pneumonia, use of brain imaging (surrogate for oversedation and neurological events), and length of stay after drug initiation RESULTS: In the propensity score-matched cohort, median treatment duration was 3 days (interquartile range (IQR) 1-6 days) for atypical APMs and 2 days (IQR 1-3 days) for typical A

SUBMITTER: Kim DH 

PROVIDER: S-EPMC5478449 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature