Intestinal microbial dysbiosis aggravates the progression of Alzheimer's disease in Drosophila.

ABSTRACT: Neuroinflammation caused by local deposits of Aβ₄₂ in the brain is key for the pathogenesis and progression of Alzheimer's disease. However, inflammation in the brain is not always a response to local primary insults. Gut microbiota dysbiosis, which is recently emerging as a risk factor for psychiatric disorders, can also initiate a brain inflammatory response. It still remains unclear however, whether enteric dysbiosis also contributes to Alzheimer's disease. Here we show that in a Drosophila Alzheimer's disease model, enterobacteria infection exacerbated progression of Alzheimer's disease by promoting immune hemocyte recruitment to the brain, thereby provoking TNF-JNK mediated neurodegeneration. Genetic depletion of hemocytes attenuates neuroinflammation and alleviated neurode

SUBMITTER: Wu SC 

PROVIDER: S-EPMC5478647 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature