Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo.

ABSTRACT: Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection. In addition, an immune modulatory role of ficolins has been suggested. Yet, the contribution of ficolins to inflammatory disease processes remains elusive. To address this, we investigated ficolin deficient mice during a lipopolysaccharide (LPS)-induced model of systemic inflammation. Although murine serum ficolin was shown to bind LPS in vitro, there was no difference between wildtype and ficolin deficient mice in morbidity and mortality by LPS-induced inflammation. Moreover, there was no difference between wildtype and ficolin deficient mice in the inflammatory cyt

SUBMITTER: Genster N 

PROVIDER: S-EPMC5478672 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature