Frailty and long-term mortality of older breast cancer patients: CALGB 369901 (Alliance).

ABSTRACT:

Purpose

Breast cancer patients aged 65+ ("older") vary in frailty status. We tested whether a deficits accumulation frailty index predicted long-term mortality.

Methods

Older patients (n = 1280) with non-metastatic, invasive breast cancer were recruited from 78 Alliance sites from 2004 to 2011, with follow-up to 2015. Frailty categories (robust, pre-frail, and frail) were based on 35 baseline illness and function items. Cox proportional hazards and competing risk models were used to calculate all-cause and breast cancer-specific mortality for up to 7 years, respectively. Potential covariates included demographic, psychosocial, and clinical factors, diagnosis year, and care setting.

Results

Patients were 65-91 years old. Most (76.6%) were robust; 18.3% were pre-frail,

SUBMITTER: Mandelblatt JS 

PROVIDER: S-EPMC5479131 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature