Ontology highlight
ABSTRACT:
SUBMITTER: Poh AR
PROVIDER: S-EPMC5479329 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cancer cell 20170401 4
Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) triggers hematological malignancies as a tumor cell-intrinsic oncogene. Here we find that high HCK levels correlate with reduced survival of colorectal cancer patients. Likewise, increased Hck activity in mice promotes the growth of endogenous colonic malignancies and of human colorectal cancer cell xenografts. Furthermore, tumor-associated macrophages of the corresponding tumors show a pronounced alternatively activate ...[more]