Genome-Wide Association Study of Post-Traumatic Stress Disorder in Two High-Risk Populations.

ABSTRACT: Mexican Americans (MAs) and American Indians (AIs) constitute conspicuously understudied groups with respect to risk for post-traumatic stress disorder (PTSD), especially in light of findings showing racial/ethnic differences in trauma exposure and risk for PTSD. The purpose of this study was to examine genetic influences on PTSD in two minority cohorts. A genome-wide association study (GWAS) with sum PTSD symptoms for trauma-exposed subjects was run in each cohort. Six highly correlated variants in olfactory receptor family 11 subfamily L member 1 (OR11L1) were suggestively associated with PTSD in the MA cohort. These associations remained suggestively significant after permutation testing. A signal in a nearby olfactory receptor on chromosome 1, olfactory receptor family 2 subfamily L me

SUBMITTER: Melroy-Greif WE 

PROVIDER: S-EPMC5479352 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature