Hypoxia regulates ANXA1 expression to support prostate cancer cell invasion and aggressiveness.

ABSTRACT: Annexin A1 (ANXA1) is a Ca²⁺-binding protein overexpressed in the invasive stages of prostate cancer (PCa) development; however, its role in this tumor metastatization is largely unknown. Moreover, hypoxic conditions in solid tumors have been related to poor prognosis in PCa patients. We have previously demonstrated that ANXA1 is implicated in the acquisition of chemo-resistant features in DU145 PCa cells conferring them a mesenchymal/metastatic phenotype. In this study, we have investigated the mechanisms by which ANXA1 regulates metastatic behavior in LNCaP, DU145 and PC3 cells exposed to hypoxia. ANXA1 was differentially expressed by PCa cell lines in normoxia whereas hypoxic stimuli resulted in a significant increase of protein expression. Additionally, in low oxygen conditi

SUBMITTER: Bizzarro V 

PROVIDER: S-EPMC5479448 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature