Three-dimensional cell shapes and arrangements in human sweat glands as revealed by whole-mount immunostaining.

ABSTRACT: Because sweat secretion is facilitated by mechanical contraction of sweat gland structures, understanding their structure-function relationship could lead to more effective treatments for patients with sweat gland disorders such as heat stroke. Conventional histological studies have shown that sweat glands are three-dimensionally coiled tubular structures consisting of ducts and secretory portions, although their detailed structural anatomy remains unclear. To better understand the details of the three-dimensional (3D) coiled structures of sweat glands, a whole-mount staining method was employed to visualize 3D coiled gland structures with sweat gland markers for ductal luminal, ductal basal, secretory luminal, and myoepithelial cells. Imaging the 3D coiled gland structures demonstrated th

SUBMITTER: Kurata R 

PROVIDER: S-EPMC5479532 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature