Genetic susceptibility in Juvenile Myoclonic Epilepsy: Systematic review of genetic association studies.

ABSTRACT:

Background

Several genetic association investigations have been performed over the last three decades to identify variants underlying Juvenile Myoclonic Epilepsy (JME). Here, we evaluate the accumulating findings and provide an updated perspective of these studies.

Methodology

A systematic literature search was conducted using the PubMed, Embase, Scopus, Lilacs, epiGAD, Google Scholar and Sigle up to February 12, 2016. The quality of the included studies was assessed by a score and classified as low and high quality. Beyond outcome measures, information was extracted on the setting for each study, characteristics of population samples and polymorphisms.

Results

Fifty studies met eligibility criteria and were used for data extraction. With a single exception, all studi

SUBMITTER: Santos BPD 

PROVIDER: S-EPMC5479548 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature