Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans.

ABSTRACT:

Background

African Americans (AA) are disproportionately affected by hypertension-related health disparities. Apolipoprotein L1 (APOL1) risk variants are associated with kidney disease in hypertensive AAs.

Objectives

This study assessed the APOL1 risk alleles' association with blood pressure traits in AAs.

Methods

The discovery cohort included 5,204 AA participants from Mount Sinai's BioMe biobank. Replication cohorts included additional BioMe (n = 1,623), Vanderbilt BioVU (n = 1,809), and Northwestern NUgene (n = 567) AA biobank participants. Single nucleotide polymorphisms determining APOL1 G1 and G2 risk alleles were genotyped in BioMe and imputed in BioVU/NUgene participants. APOL1 risk alleles' association with blood pressure-related traits was tested in the disc

SUBMITTER: Nadkarni GN 

PROVIDER: S-EPMC5479565 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature