The myeloma stem cell concept, revisited: from phenomenology to operational terms.

ABSTRACT: The concept of the myeloma stem cell may have important therapeutic implications, yet its demonstration has been hampered by a lack of consistency in terms and definitions. Here, we summarize the current documentation and propose single-cell in vitro studies for future translational studies. By the classical approach, a CD19^-/CD45^low/-/CD38^high/CD138⁺ malignant plasma cell, but not the CD19⁺/CD38^low/- memory B cell compartment, is enriched for tumorigenic cells that initiate myeloma in xenografted immunodeficient mice, supporting that myeloma stem cells are present in the malignant PC compartment. Using a new approach, analysis of c-DNA libraries from CD19⁺/CD27⁺/CD38^- single cells has identi

SUBMITTER: Johnsen HE 

PROVIDER: S-EPMC5479618 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature