Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation.

ABSTRACT: T cell activation and especially trafficking of T cell receptor microclusters during immunological synapse formation are widely thought to rely on cytoskeletal remodeling. However, important details on the involvement of actin in the latter transport processes are missing. Using a suite of advanced optical microscopes to analyze resting and activated T cells, we show that, following contact formation with activating surfaces, these cells sequentially rearrange their cortical actin across the entire cell, creating a previously unreported ramifying actin network above the immunological synapse. This network shows all the characteristics of an inward-growing transportation network and its dynamics correlating with T cell receptor rearrangements. This actin reorganization is accompanied by an

SUBMITTER: Fritzsche M 

PROVIDER: S-EPMC5479650 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature