Impaired N-linked glycosylation of uptake and efflux transporters in human non-alcoholic fatty liver disease.

ABSTRACT:

Background & aims

N-linked glycosylation of proteins is critical for proper protein folding and trafficking to the plasma membrane. Drug transporters are one class of proteins that have reduced function when glycosylation is impaired. N-linked glycosylation of plasma proteins has also been investigated as a biomarker for several liver diseases, including non-alcoholic fatty liver disease (NAFLD). The purpose of this study was to assess the transcriptomic expression of genes involved in protein processing and glycosylation, and to determine the glycosylation status of key drug transporters during human NAFLD progression.

Methods

Human liver samples diagnosed as healthy, steatosis, and non-alcoholic steatohepatitis (NASH) were analysed for gene expression of glycosylation-rela

SUBMITTER: Clarke JD 

PROVIDER: S-EPMC5479731 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature