Mycobacterial heat shock protein 65 mediated metabolic shift in decidualization of human endometrial stromal cells.

ABSTRACT: Successful implantation is dependent on the appropriate decidualization of endometrial stromal cells for the establishment of pregnancy in women. Mycobacterial heat shock protein 65 (HSP65) is involved in pathogenesis of the genital tuberculosis (GTB), one of the common causes of infertility in emerging countries. Though implantation failure appears to be the major cause, understanding the status of decidualizaiton process in women diagnosed with GTB has not been thoroughly addressed. We, therefore, explored the effect of HSP65 protein on the endometrial cell metabolism during in vitro decidualization. In order to identify the cellular metabolism of decidual cells with and without HSP65 treatment, proton NMR based characterization of metabolites extracted from cells and culture media were

SUBMITTER: Subramani E 

PROVIDER: S-EPMC5479817 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature