Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder.

ABSTRACT:

Objectives

Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). Few studies, however, have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy counterpart (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging.

Design

Cross-sectional study.

Setting

University of California San Diego and the Veterans Administration San Diego Healthcare System.

Participants

33 euthymic BD and 38 HC participants.

Measurements

Diffusion tensor imaging was acquired as a measure of WM int

SUBMITTER: Dev SI 

PROVIDER: S-EPMC5479871 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature