RelB⁺ Steady-State Migratory Dendritic Cells Control the Peripheral Pool of the Natural Foxp3⁺ Regulatory T Cells.

ABSTRACT: Thymus-derived natural Foxp3⁺ CD4⁺ regulatory T cells (nTregs) play a key role in maintaining immune tolerance and preventing autoimmune disease. Several studies indicate that dendritic cells (DCs) are critically involved in the maintenance and proliferation of nTregs. However, the mechanisms how DCs manage to keep the peripheral pool at constant levels remain poorly understood. Here, we describe that the NF-κB/Rel family transcription factor RelB controls the frequencies of steady-state migratory DCs (ssmDCs) in peripheral lymph nodes and their numbers control peripheral nTreg homeostasis. DC-specific RelB depletion was investigated in CD11c-Cre × RelB^fl/fl mice (RelB^DCko), which showed normal frequencies of resident DCs in lymph nodes and splee

SUBMITTER: Dohler A 

PROVIDER: S-EPMC5479892 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature