Neurophysiological mechanisms of circadian cognitive control in RLS patients - an EEG source localization study.

ABSTRACT: The circadian variation of sensory and motor symptoms with increasing severity in the evening and at night is a key diagnostic feature/symptom of the restless legs syndrome (RLS). Even though many neurological diseases have shown a strong nexus between motor and cognitive symptoms, it has remained unclear whether cognitive performance of RLS patients declines in the evening and which neurophysiological mechanisms are affected by the circadian variation. In the current study, we examined daytime effects (morning vs. evening) on cognitive performance in RLS patients (n = 33) compared to healthy controls (n = 29) by analyzing flanker interference effects in combination with EEG and source localization techniques. RLS patients showed larger flanker interference effects in the evening than in t

SUBMITTER: Zhang R 

PROVIDER: S-EPMC5480014 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature