Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study.

ABSTRACT: Objective To test the hypotheses that physical activity in midlife is not associated with a reduced risk of dementia and that the preclinical phase of dementia is characterised by a decline in physical activity.Design Prospective cohort study with a mean follow-up of 27 years.Setting Civil service departments in London (Whitehall II study).Participants 10 308 participants aged 35-55 years at study inception (1985-88). Exposures included time spent in mild, moderate to vigorous, and total physical activity assessed seven times between 1985 and 2013 and categorised as "recommended" if duration of moderate to vigorous physical activity was 2.5 hours/week or more.Main outcome measures A battery of cognitive tests was administered up to four times from 1997 to

SUBMITTER: Sabia S 

PROVIDER: S-EPMC5480222 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature