Total synthesis of TMG-chitotriomycin based on an automated electrochemical assembly of a disaccharide building block.

ABSTRACT: The total synthesis of TMG-chitotriomycin using an automated electrochemical synthesizer for the assembly of carbohydrate building blocks is demonstrated. We have successfully prepared a precursor of TMG-chitotriomycin, which is a structurally-pure tetrasaccharide with typical protecting groups, through the methodology of automated electrochemical solution-phase synthesis developed by us. The synthesis of structurally well-defined TMG-chitotriomycin has been accomplished in 10-steps from a disaccharide building block.

SUBMITTER: Isoda Y 

PROVIDER: S-EPMC5480352 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature