Improving survival prognostication of gastroenteropancreatic neuroendocrine neoplasms: Revised staging criteria.

ABSTRACT:

Purpose

Current staging criteria for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), while useful, have limitations. In this study, we used a population-based registry to evaluate the prognostic utility of the current staging systems and assess whether evidence-based modifications can improve survival predictions.

Methods

We identified patients with confirmed GEP-NENs from the Surveillance, Epidemiology and End Results registry. We assigned tumour-node-metastasis status according to American Joint Committee on Cancer and European Neuroendocrine Tumor Society criteria. We derived a revised staging classification using Kaplan-Meier methods and Cox regression to assess disease-specific survival and compared the accuracy of potential models based on the Akaike Inform

SUBMITTER: Martin JA 

PROVIDER: S-EPMC5480456 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature