PubChem BioAssay: A Decade's Development toward Open High-Throughput Screening Data Sharing.

ABSTRACT: High-throughput screening (HTS) is now routinely conducted for drug discovery by both pharmaceutical companies and screening centers at academic institutions and universities. Rapid advance in assay development, robot automation, and computer technology has led to the generation of terabytes of data in screening laboratories. Despite the technology development toward HTS productivity, fewer efforts were devoted to HTS data integration and sharing. As a result, the huge amount of HTS data was rarely made available to the public. To fill this gap, the PubChem BioAssay database ( https://www.ncbi.nlm.nih.gov/pcassay/ ) was set up in 2004 to provide open access to the screening results tested on chemicals and RNAi reagents. With more than 10 years' development and contributions from the commun

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5480605 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature