Factors associated with fractures in HIV-infected persons: which factors matter?

ABSTRACT: This study aims to determine what factors are associated with increased risk of fracture among patients with HIV, in particular whether an important medication used to treat HIV, tenofovir, is associated with fracture. Our study found that while co-infection with hepatitis C and markers of HIV severity were associated with fracture, tenofovir was not.

Introduction

Growing evidence suggests that tenofovir disoproxil fumarate decreases bone density among patients with HIV, but there are conflicting reports as to whether this decrease in bone density translates to higher fracture risk. We aimed to determine what factors were associated with an increased risk of fracture for patients with HIV, in particular whether tenofovir is associated with elevated fracture risk.

Methods

We c

SUBMITTER: Gedmintas L 

PROVIDER: S-EPMC5480613 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature