Genome-Wide Identification and Comparative Analysis of Albumin Family in Vertebrates.

ABSTRACT: Albumins are the most well-known globular proteins, and the most typical representatives are the serum albumins. However, less attention was paid to the albumin family, except for the human and bovine serum albumin. To characterize the features of albumin family, we have mined all the putative albumin proteins from the available genome sequences. The results showed that albumin is widely distributed in vertebrates, but not present in the bacteria and archaea. The phylogenetic analysis of vertebrate albumin family implied an evolutionary relationship between members of serum albumin, α-fetoprotein, vitamin D-binding protein, and afamin. Meanwhile, a new member from the albumin family was found, namely, extracellular matrix protein 1. The structural analysis revealed that the motifs for form

SUBMITTER: Li S 

PROVIDER: S-EPMC5480655 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature