The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions.

ABSTRACT:

Aim

The effect of a gene-expression-based test on treatment of melanocytic neoplasms by dermatologists was evaluated.

Patients & methods

Pathologists submitted diagnostically challenging melanocytic neoplasms to a clinical laboratory for testing accompanied by pretest surveys documenting the intended treatment recommendations. The actual treatment rendered by dermatologists was then documented after testing. Changes between the pretest recommendations and actual treatment were analyzed.

Results

In 71.4% (55/77) of cases, there was a change from pretest recommendations to actual treatment. The majority of changes were consistent with the test result. There was an 80.5% (33/41) reduction in the number of biopsy site re-excisions performed for cases with a benign test re

SUBMITTER: Cockerell C 

PROVIDER: S-EPMC5480781 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature