Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy.

ABSTRACT: Traditional genome-wide scans for positive selection have mainly uncovered selective sweeps associated with monogenic traits. While selection on quantitative traits is much more common, very few signals have been detected because of their polygenic nature. We searched for positive selection signals underlying coronary artery disease (CAD) in worldwide populations, using novel approaches to quantify relationships between polygenic selection signals and CAD genetic risk. We identified new candidate adaptive loci that appear to have been directly modified by disease pressures given their significant associations with CAD genetic risk. These candidates were all uniquely and consistently associated with many different male and female reproductive traits suggesting selection may have also target

SUBMITTER: Byars SG 

PROVIDER: S-EPMC5480811 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature