The genetic landscape of breast carcinomas with neuroendocrine differentiation.

ABSTRACT: Neuroendocrine breast carcinomas (NBCs) account for 2-5% of all invasive breast cancers, and are histologically similar to neuroendocrine tumours from other sites. They typically express oestrogen receptor (ER), and are HER2-negative and of luminal 'intrinsic' subtype. Here, we sought to define the mutational profile of NBCs, and to investigate whether NBCs and common forms of luminal (ER⁺ /HER2^- ) breast carcinoma show distinct repertoires of somatic mutations. Eighteen ER⁺ /HER2^- NBCs, defined as harbouring >50% of tumour cells expressing chromogranin A and/or synaptophysin, and matched normal tissues were microdissected and subjected to massively parallel sequencing targeting all exons of 254 genes most frequently mutated in breast carcinomas

SUBMITTER: Marchio C 

PROVIDER: S-EPMC5481202 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature