Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas.

ABSTRACT: The microbiome is fundamentally one of the most unique organs in the human body. Dysbiosis can result in critical inflammatory responses and result in pathogenesis contributing to neoplastic events. We used a pan-pathogen array technology (PathoChip) coupled with next-generation sequencing to establish microbial signatures unique to human oral and oropharyngeal squamous cell carcinomas (OCSCC/OPSCC). Signatures for DNA and RNA viruses including oncogenic viruses, gram positive and negative bacteria, fungi and parasites were detected. Cluster and topological analyses identified 2 distinct groups of microbial signatures related to OCSCCs/OPSCCs. Results were validated by probe capture next generation sequencing; the data from which also provided a comprehensive map of integration sites and c

SUBMITTER: Banerjee S 

PROVIDER: S-EPMC5481414 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature