Inhibition of transmembrane member 16A calcium-activated chloride channels by natural flavonoids contributes to flavonoid anticancer effects.

ABSTRACT:

Background and purpose

Natural flavonoids are ubiquitous in dietary plants and vegetables and have been proposed to have antiviral, antioxidant, cardiovascular protective and anticancer effects. Transmembrane member 16A (TMEM16A)-encoded Ca²⁺ -activated Cl^- channels play a variety of physiological roles in many organs and tissues. Overexpression of TMEM16A is also believed to be associated with cancer progression. Therefore, inhibition of TMEM16A current may be a potential target for cancer therapy. In this study, we screened a broad spectrum of flavonoids for their inhibitory activities on TMEM16A currents.

Experimental approach

A whole-cell patch technique was used to record the currents. The BrdU assay and transwell technique were used to investigate

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5481650 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature